Negative Results | Preemptive effect of ibuprofen associated with arginine on endodontic flare-up
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Preemptive effect of ibuprofen associated with arginine on endodontic flare-up

Amanda Regina Fischborn1, Caique Mariano Pedroso1, Jessica Daniela Andreis1, Bruna Carolyne Siefert de Oliveira1, Tuane luchinski Saad2, Fábio Brasil de Oliveira2, Camila Maggi Maia Silveira2, Eduardo Bauml Campagnoli1, Marcelo Carlos Bortoluzzi1, Gilson Cesar Nobre Franco1, Marcela Claudino1

1 Department of Dentistry, State University of Ponta Grossa, Ponta Grossa, ZIP Code: 84030-900, Brazil
2 Department of Dentistry, Higher Education Center of Campos Gerais, Ponta Grossa, ZIP Code: 84030-000, Brazil

Adress: Gilson Cesar Nobre Franco.
Department of Dentistry, State University of Ponta Grossa, Ponta Grossa,
Avenue Carlos Cavalcanti,
ZIP Code: 84030-900, Brazil.

E-mail: gilsoncnf@gmail.com

Abstract
Background: a flare-up is defined as pain and/or swelling of periapical tissues after a few hours or days following endodontic procedures. The purpose of this study was to evaluate the effect of a single preoperative dose of ibuprofen and ibuprofen with arginine in the control of endodontic flare-ups. This study also assessed the influence of endodontic therapy on individuals’ quality of life through questionnaires.
Methods: Seventy-eight volunteers were divided into three groups: Placebo (n=34), Ibuprofen (n=33, dosage of 400mg), and Ibuprofen with arginine (n=33, dosage of 400mg). Measurements of post-endodontic pain intensity with a numerical rating scale were performed after 6, 12, 24, 48, and 72 hours. OHIP scores were obtained before and after endodontic treatment and the consumption of rescue medication was also recorded after endodontic procedures.
Results: No significant differences were detected between groups regarding pain intensity and the number of rescue medication tablets. Moreover, no significant difference in the OHIP scores in the pre- and post-treatment periods in the placebo group. However, there was a reduction in these scores after treatment in the ibuprofen (p=0.0458) and ibuprofen with arginine (p=0.0474) groups.
Conclusion: No differences were detected regarding pain intensity, number of rescue medication tablets, and OHIP scores with the preemptive use of ibuprofen with arginine compared to placebo and ibuprofen groups. Therefore, further studies should be carried out for a better understanding of the preemptive use of ibuprofen with arginine in an endodontic flare-up.
Keywords: Ibuprofen, Ibuprofen arginine, Symptom Flare Up, Clinical Trial.

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Preemptive effect of ibuprofen associated with arginine on endodontic flare-up

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