Negative Results | No observable sleep disturbance in two rat models with induced osteoarthritis
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No observable sleep disturbance in two rat models with induced osteoarthritis

Havel, D.1, Kleinschmidt-Doerr, K1, Gernert, M2, Michaelis, M1, Lindemann, S1, Guehring, H1

1 Translational Osteoarthritis, TIP Immunology, Merck KGaA, Darmstadt, Germany
2 Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Germany

Adress: Central Research Facilities, Goethe University, Frankfurt a. M., Germany.
E-mail: daniel.havel@kgu.de

Abstract
Sleep deprivation due to pain is commonly regarded as a major impairment for patients with osteoarthritis (OA). To enable research for relieving OA related pain and subsequent changes in sleep patterns, two OA rat models, one surgically and one chemically induced model, were examined to assess and quantify occurrence of pain-induced sleep disturbance. Using chronically implanted electrodes, sleep patterns were analyzed based on EEG and EMG recordings. The development of OA-like lesions in both models was confirmed by histology or gross morphology. In the used setup, sleep was quantifiable and a significantly increasing effect on sleep efficiency (SE) of thalidomide was observed while SE significantly decreased after application of buprenorphine, as expected. In this study, OA itself did not induce any observable effect on sleep compared to healthy control groups. However, the occurrence of OA pain related sleep disturbance in experimental animals cannot be excluded because a decreased bodyweight and general condition score and an increased home cage activity indicate a greater than expected burden of the recording system itself.

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